From 1922 he also worked as a university professor, and a year later he became the Rector of the Academy of Fine Arts in Zagreb. He exhibited his work in all major museums worldwide, both in solo and group exhibitions. Some of his best solo exhibitions include the exhibition at XI. Biennale in Venice, in the Victoria and Albert Museum in London, Paris, Prague, New York, Buffalo, Detroit, Rochester, Chicago, St. Louis, Boston and Cleveland. In 1947, at the invitation of the American Academy of Arts and Sciences, exhibition of his work was presented at the Metropolitan Museum in New York which made Meštrović the first living artist whose exhibition was organized by the Museum. In 1947 he moved to the United States where he worked as a professor at the School of Arts at Syracuse University, New York. From 1955 he taught at postgraduate studies at the University of Notre Dame, South Bend, Indiana. He passed away in Indiana, on January 16th, 1962. He was buried on January 24th in the family tomb in the Church of the Holy Redeemer, in Ružić near Otavice.

Meštrović’s art works are exhibited all over Croatia and worldwide. He dedicated and then donated a substantial part of his work to his homeland. Near Otavice he designed and had built The Holly Redeemers' Church, his family tomb, and he also designed the school building and the public care facility in Otavice. His art works can also be seen in Drniš. Drniš City Museum exhibits Meštović’s sculptures and paintings, a sculpture of Our Lady of Petrovo polje can be seen at the main altar of the Parish church of Our Lady of the Rosary. Fountain The Spring of Life, relief The Ploughmen and sculpture Mother and Child are available to visitors on Drniš public surfaces.